Key Step For Origin Of Life Observed In Lab

Today, chemists regularly make catalysts that will steer a reaction towards products in one particular left or right form. Known as asymmetric reactions, they are commonly used in the pharmaceutical industry to make drugs which are active in the body in only one of the chiral forms.

“Chemists today can make templates to steer towards one form or another, but what happened at the beginning of the world when no such templates existed?” asks Professor Donna Blackmond, Professor of Catalysis at Imperial and senior author on the paper.

Over 50 years ago, a theorist explained how domination of one chiral form may arise. F.C. Frank suggested in 1953 that a tiny amount of one particular chiral form may become amplified into an excess over the other, through a process known as autocatalysis where the substance acts as a catalyst for producing more of itself. His paper concluded with the teasing words: “A laboratory demonstration may not be impossible.”

Until 1995, researchers searched in vain to conquer what had been further ‘dubbed a challenge to all red-blooded chemists’. That year Kenso Soai and colleagues from Tokyo University demonstrated the first reaction to meet the Frank criteria, using an organozinc compound as catalyst.

In 2003, Professor Blackmond first heard reports by chemists at the Scripps Research Institute of a new reaction catalysed by proline, an amino acid.

What caught her eye was that the reaction appeared to be much faster than other proline-catalysed reactions.

Back in her laboratories she began to run the reaction, analysing it with sensitive calorimetry equipment that continuously monitors its rate. Proline indeed catalysed the reaction, exhibiting an unexpectedly high, accelerating reaction rate and an amplification of product excess in one particular chiral form; both tell-tale signs of a reaction that can rationalize the evolution of biological homochirality.

“This work may offer the first purely organic complement to the Soai reaction in the search for the chemical origin of life,” says Professor Blackmond.

The research was supported by EPSRC/DTI/LINK and Mitsubishi Pharma. Parts of the experimental work were carried out in the Department of Chemistry, University of Hull, where Professor Blackmond previously worked.