science Tuesday, September 15, 2009 . This is a SciScoop post by David Bradley
The Blah Blah Tech blog often gets me thinking. Recently, tech author Wayne Smallman posted an item about how DNA is hardwired into the universe. It’s an interesting read, but there were a couple of points of fact that I wanted to pick up on and a critique of the conclusions I wanted to make.
First, Wayne quotes from another article about DNA, life, the universe, and everything, that makes a factual error:
“A recent mathematical analysis says that life as we know it is written into the laws of reality. DNA is built from a set of twenty amino acids — the first ten of those can create simple prebiotic life, and now it seems that those ten are … destined to occur wherever they can.”
DNA, of course, is not built from 20 amino acids at all. Proteins are built from amino acids. DNA is built from bases and there are four of those. They are usually labelled G,T,C, and A (hence the 1997 movie title Gattaca about a genetically “different” man).
In the subsequent paragraph, Wayne then states that DNA is the building block of life. Again, that would be proteins. DNA is the template against which protein chains of amino acids are constructed and then “fold” into their active forms, which are then considered the building blocks of life.
But, the main thrust of the article is that somehow the structure of DNA is somehow woven into the fabric of reality. Well, it is for terrestrial life, but I think it’s wishful thinking if we are to suggest that should there happen to be life elsewhere in the universe that it too would utilise the same four simple chemicals – G,T,C,A, to construct self-replicating molecules that then build other molecules to produce their life stuff.
We can say nothing yet about life elsewhere and whether amino acids and so proteins are essential to life, they may not be. The actual notion that life is somehow intrinsically fundamental because of patterns is quite a fanciful idea. There are patterns and fundamental ones at that seen in life on earth. But, we have absolutely no evidence that these “patterns” have emerged anywhere else in the universe, life here really could be a total and utter fluke.
There may be some peculiar self-replicating crystalline system based on high-pressure inorganic chemistry that exists under the extreme conditions of a whirling gas giant planet orbiting a distant brown dwarf, or some vapour-like entity hovering low on a distant moon, who knows? Certainly, the writers of science fiction and fanciful research papers don’t.
Meanwhile, those alien crystals or extraterrestrial vapours may, right now, be puzzling over the mathematics of symmetry and Boltzmann’s constant and anticipating the discovery of other crystalline or gaseous lifeforms elsewhere in the universe. Forgetting that while chemistry is universal, it is not all organic.

Previously: « Tomorrow’s World Tipoff
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4 Responses to Finding Inorganic Life
JS
September 15th, 2009 at 12:20 pm
This is one of the great questions – assuming there is other life in the universe (pretty much a given), what is the nature of their genetic code?
The fist extra terrestrial species we find will either be DNA-based or not. If it isn’t then it will be astonishing to see the emergence of another self-replicating, genetic code.
If it IS DNA based then the suggestion that DNA is somehow one of the fundamental properties of reality becomes more likely (I’ve always found that prospect quite appealing).
It seems more likely however that that there are a suite of potential substances that can become self-replicating genetic codes.
And Gattaca was not really about a genetically inferior man btw :) It’s more about how, in an age where genetics has become the socially assumed metric for achievement, humanity can still exceed it’s genetic foundation regardless of it’s advantages or disadvantages.
It’s summed up after the concert scene:
“Twelve fingers or one it’s how you play” – Vincent
“That piece can only be played with twelve” – Irene
Hector
September 15th, 2009 at 12:26 pm
Evolutionary scientists have thought long and hard about this topic for many years. There is a unique condition on earth in which carbon has been the base of the evolution of life over the historical records available to us. That being said, nucleotide bases seem to have come much later in the development of replicative life. If you examine the primary metabolic pathways in all organisms, they all center around CO2 manipulation of a central carbon core. Nitrogen fixation only comes in along the secondary pathways of amino acid chemistry (proposed by A. G. Cairns-Smith, Freeman Dyson, Hyman Hartman, and others). Reviewing the substrates and difficult chemistry required for nucleotide base assembly, the data points at a later evolution of RNA/DNA life. Even though a Nature paper this year, Nature 459, 239-242 (14 May 2009), seems to add more credence to the idea of a self assembling nucleotide base from prebiotic organic molecules, there still remains the issue of assembling enough starting material for these chemical reactions to occur.
The availability of new genetic algorithms and more molecular data from genomic sequencing studies is providing a nice test bed for addressing some of these hypotheses.
David Bradley
September 15th, 2009 at 6:57 pm
I don’t think it’s a given that there is extraterrestrial life that we could encounter. It’s more probable that there has been extraterrestrial life previously elsewhere and that it might emerged somewhere else again in the future.
Why is it appealing that ET would use DNA? I think it would be even more fascinating if there were greater diversity of self-replicating chemical systems and some kind of exo-biochemistry that we have not yet even vaguely imagined…
I wrote about the work of Reza Ghadiri almost two decades ago…he was using non-DNA systems to create self-replicating molecules, albeit carbon-based. Carbon is special after all in being able to concatenate to such a degree as no other element can. So, I wouldn’t be surprised if there were extraterrestrials made of carbon compounds, but I doubt they’d use GTCA…
(Yes, not inferior…different)
David Bradley
September 18th, 2009 at 9:20 am
Scientists at a new interdisciplinary research institute in Austria are working to uncover how life might evolve with “exotic” biochemistry and solvents, such as sulphuric acid instead of water. Their research will be presented at the European Planetary Science Congress in Potsdam by Dr Johannes Leitner on Friday 18 September.
http://www.alphagalileo.org/ViewItem.aspx?ItemId=61129&CultureCode=en