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We Don’t Understand Hangovers

science Wednesday, July 15, 2009 . This is a SciScoop post by David Bradley

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Some typical alcoholic beverages.
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Gemma Prat of the Department of Psychiatry and Clinical Psychobiology, School of Psychology, University of Barcelona, Spain, explains in a research review paper earlier this year, that despite claims to the contrary, we really don’t yet fully understand what causes alcohol hangovers. There are, of course, plenty of theories, and even more home-spun remedies…

Anyone who has ever had one too many alcoholic beverages will know all too well the misery of the morning after the night before.

The “symptoms” of hangover vary, but a combination of any of the following may define someone as hungover:

Distress, anxiety, tachycardia, tiredness, increased arterial tension, weakness, palpitations, thirst, tremor, nausea, headache, diarrhea, muscular cramps loss of appetite, stomach pain, decreased attention, sensitivity to light, memory problems, sensitivity to loud noise, poor concentration, dizziness, poor sleep, irritability, depression.

There are various concepts about what actually causes a hangover: poisoning by the alcohol in the drink itself, toxic metabolites of alcohol, alcohol withdrawal, or the toxic effects of other compounds commonly found in alcoholic drinks, particularly highly colored beverages. It may be that any one of these or various combinations is to blame. We don’t yet know. “All of them are partial, explaining different aspects of hangover or how several factors are able to modify its appearance and severity,” say Prat and her colleagues.

What we do know is that thousands of people suffer every morning, and many productive days are lost because of overindulgence. Prat’s paper aims to review the concept of hangover, how it progresses, and to suggest how new research might improve our knowledge of this rather unpleasant phenomenon. It might even one day lead to a way of preventing hangover without those who enjoy a tipple having to abstain totally. (Maybe that’s not a good thing…)

Research Blogging IconPrat, G., Adan, A., & Sánchez-Turet, M. (2009). Alcohol hangover: a critical review of explanatory factors Human Psychopharmacology: Clinical and Experimental, 24 (4), 259-267 DOI: 10.1002/hup.1023

4 Responses to We Don’t Understand Hangovers

wazza

July 15th, 2009 at 10:56 pm

You forgot the theory (espoused quite commonly amongst my friends) that the metabolization of alcohol requires large amounts of water, dehydrating the body, causing headaches, sticky mouth etc. I have found that a hangover can be reduced to nothing more than a slightly queasy stomach by drinking a lot of water before bed after a night on the town.

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David Bradley

July 16th, 2009 at 7:49 am

Yes, water, or lack thereof, does play a role in the development of a hangover, but it is not the whole story for everyone and the beneficial effects you and your friends observe doesn’t necessarily home in on the actual causative agents. Indeed, it could be that you are simply diluting the residual alcohol in your gut rather than staving off a hangover by providing the metabolic medium for its processing.

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Neuroskeptic

July 16th, 2009 at 3:59 pm

The only thing I’ve ever found to work to is lots of water alongside and after the alcohol. And in the morning, more water, and lots of painkillers.

Clearly dehydration can’t be the only explanation, but in my experience it’s responsible for the worst of the suffering.

but course I could be completely wrong about this. Actually, it would be interesting to research people’s beliefs about alcohol. For example, there’s the belief that mixing different kinds of drinks gets you drunk faster and leaves you with a worse hangover. I know plenty of intelligent people who swear this is true, but in my experience it’s nonsense and I just can’t see how it can be anything other than an urban myth…

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David Bradley

July 16th, 2009 at 4:10 pm

Water certainly helps, but whether it’s effective through a rehydration mechanism, a dilution effect, or some kind of metabolic effect is not clear. Indeed, it’s actually very difficult to drink sufficient to cause clinical dehydration, so it’s definitely not the whole story.

Yes, they do say that one should never mix grape and grain (wine and beer), but if that’s the case…what’s muesli all about?

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