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Rhodiola rosea redux

science Tuesday, February 23, 2010 . This is a SciScoop post by David Bradley

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Katie Jones recently read a post on Sciencebase about the herbal “remedy” Rhodiola rosea for which there is little verifiable independent evidence of efficacy. Nevertheless, the comments thread caught her attention as it shuttles back and forth between those who have faith in unproven herbal tonics and those who would prefer at least some science-based evidence to appear before imbibing plant extracts of unknown chronic toxicity.

Jones offers a neat summary of the comment thread:

1) It is insane to think that any one product can cure everyone’s problems, and while some things may benefit one person’s body, they will not necessarily benefit all people or have the same effects.

2) Most often it is a person’s will to change themselves that actually changes how their body feels, and taking pills can often serve as rituals, if you will, to convince someone that they have decided to change.

3) Trying something might be beneficial – unless you are wary of the health benefits for your body in particular, and are unwilling to risk such a thing.

4) Scientific approaches to things must be taken if you’re going to try and give a general statement that can apply to everyone – for example, just because eating a cookie is okay for one person does not mean that a diabetic person would also enjoy eating a cookie. Thus, it is silly to try and say “cookies are good for everyone” is a scientific statement.

5) Skepticism is healthy – especially in an age where “facts” often prove to be “statements that we received more money for publicizing”.

She then asked whether I personally believe in the body’s natural ability to heal itself instead of relying on outside remedies, that may or may not have additional effects besides positive ones? But, I felt that a rhetorical question of that nature should be answered rhetorically by the inquisitor and she agreed:

“I think that there is definite evidence for both answers, and that the answer of an individual on the matter reveals more about their personality (the way they view the world) than it does anything else. That said, I also think that I have a lot to learn, and either answer would give both me and the respondent a new perspective; my question was in part an attempt at creating a win-win situation.”

Personally, I think we have to be over-skeptical of the claims made by marketeers, whether they’re selling something with genuine physiological activity or snake oil. After all, if a product is physiologically active, then strictly speaking it is potentially medicine or poison, or something in between. If it has not been properly trialled who’s to say what side-effects it might be having or what contraindications there are with conventional prescription drugs.

And, speaking of which, something like 30% of prescription drugs are derived from natural products, and yes they do have side-effects, there is no such thing as a 100% risk-free medicine nor any panaceas that can treat all ailments, regardless of what the snake oil marketeers or even pharmaceutical shills might tell you.

4 Responses to Rhodiola rosea redux

Norm Gaskarth

April 21st, 2010 at 8:25 pm

I too read the post by Mr. Bradley and agree, in the main, with those who prefer science based evidence to traditional claims. However commentators such as Mr. Bradley, who profess to have a science background, should indulge in some internet training and learn how to use Google Scholar. Typing Rhodiola Rosea into that engine returns more than 2000 scientific articles on Rhodiola explaining its mechanism of action, and include a paper comparing the effect of a Rhodiola extract to the active ingredient in Prozac – (the difference in MAO inhibition is not statistically significant). The government of Alberta Canada has spent millions on Rhodiola research over the past many years and when convinced of its value supported a commercial growing program. Mr. Bradley may want to contact Dr. Kwesi Ampong-Nyarko, PhD, PAg of Alberta Agriculture to update his knowledge in this area. He was one of several scientists leading teams of investigators.
I also agree that regulation in the “nutraceuticals” industry is poor and enforcement worse. However there are some jurisdictions (Canada) that do apply much the same regulation to herbal supplements as they do pharmaceuticals. In Canada it is expected that due to new regulations in effect since January of this year, up to 80% of existing products will be removed from the shelf. For consumers (and commentators) who wish to get an idea of which products are both safe and effective, the Health Canada Natural Health Products Directorate website may be a good place to start. There both consumers and “experts” can access a list of those products awarded a Drug Identification Number or equivalent approval. Science based products with their allowed label medical claims can be found there. Finally, Mr. Bradley may wish to attend the The Natural Health Product Research Society annual conference. This year they are dedicating a session to Rhodiola and Schwabe Pharmaceuticals of Germany will be presenting Trial results for a study done on Rhodiola and Alzheimer’s.

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David Bradley

April 21st, 2010 at 8:49 pm

I don’t abide personal attacks. There may be 2000 entries, but it would be useful to know how many of those are not from
a non-curated purportedly academic search engine that has many duplicate entries and references to non-peer-reviewed research papers. It is probable that things have moved on scientifically since I wrote the original post in October 2008. However, I still don’t accept that hyperbole and unreliable claims made in press releases that make unwarranted claims without scientific evidence are worthy of publication.

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Mark J.

July 18th, 2010 at 10:58 am

I don’t think he was making a personal attack, but he does have a point: there is certainly some reliable research available on the efficacy of Rhodiola Rosea in the treatment of “X”. This is no to say that RR does everything marketeers claim, but I do think it deserves more attention. St. John’s Wort is a good example of an over the counter product that proved to work (albeit not without risks).

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David Bradley

July 19th, 2010 at 7:51 am

@Mark It was a personal attack, he made sarcastic remarks about me! My point is that the research that everyone keeps mentioning here and elsewhere seems to be very limited.

Why are people so keen to believe in fairy tales and supposed miracle cures? I see it for all kinds of nonsense remedies marketed in magazine advertorials and of course on the web.

As to St John’s Wort…well where do we start?

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