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Sleep Is Now An Option
By rickyjames, Section News
Posted on Tue Nov 11, 2003 at 12:59:20 AM PST

Cognitive Science I read a very interesting article on Provigil in the December 2003 issue of Men's Journal. It's not online, so pick a copy up at the newsstand and check it out - it's the one with Kid Rock on the cover. It's worth buying just for the other article about the 50 Best Guy Movies of All Time - which they do list online to tease you into, you got it, picking a copy up on the newsstand.

Now where was I? Oh, yes, Provigil. It was a drug originally developed to treat narcolepsy, the inability to stay awake. Now Cephalon, the maker of Provigil, has received a letter of approval from the FDA extending the approved uses of the drug to treatment of jet-lag and swing-shift syndrome. In reality the the drug is set to replace the caffeine in No-Doze as the all-nighter anti-sleep aid of choice. In fact, it's much better than No-Doze - with Provigil, you can literally stay awake for days, alert and with a remarkable lack of side effects. For example, a 1995 Canadian study showed that subjects taking the drug were able to perform well on cognitive tests while remaining awake and in good spirits for two and a half days. "This drug is going to bring up some very interesting ethical dilemmas," says Dr. Mark Mahowald, director of the Minnesota Regional Sleep Disorders Center in Minneapolis and an expert on the causes of daytime sleepiness. "Do you prescribe a stimulant medication for someone who is intentionally sleep deprived?"

For soldiers, the answer is yes. In another study, published in 2000, U.S. Army helicopter pilots stayed awake for 40 hours while being called upon periodically to perform maneuvers on a flight simulator. Unmedicated, the aviators became sloppy and made errors in the early morning hours. But while taking Provigil during a second 40-hour marathon, their skills and focus never wavered. Army psychologist John Caldwell, who conducted the latter study, says more research is needed to determine whether dosing soldiers with Provigil is a safe and effective way to promote alertness. However, he says, it's possible that one day the drug could be used "as an emergency measure to briefly overcome fatigue in 'must-do' missions where total sleep deprivation is unavoidable."

So...want some? Or maybe you'd prefer a drug to erase your fears and phobias...

Sleep Is Now An Option | 13 comments (13 topical, 0 hidden)

It works (5.00 / 2) (#4)
by koreth on Tue Nov 11, 2003 at 01:08:36 PM PST
Luckily, doctors have been able to prescribe this stuff for conditions other than narcolepsy since it was initially approved. My work sometimes requires me to keep a pretty erratic sleep schedule, so I've been taking Provigil an average of about once a week for the last year and a half or so. It's wonderful stuff.

On one level I am aware that I haven't gotten enough sleep, but when my mind would ordinarily start getting foggy and my eyes would start drooping, the tired feeling remains very far in the background, something I can note and then ignore. There is none of the giddy, twitchy, jumpy feeling I used to get when I drank caffeinated beverages. And in fact, I've more or less completely stopped drinking them -- caffeine's side effects become much more noticeable when you have something better to compare it with.

Where caffeine prevents you from going to sleep, Provigil stops you from *wanting* to go to sleep. Big difference in my book.

I have never tried using it to completely skip a night's sleep, so I'm not sure what that would feel like. But I can easily see this stuff being included in half the junk food on the market a few years from now, just like caffeine is today. Unless there's some hidden damage being done to my internal organs, Provigil feels less harmful than caffeine, and it works a lot better too.



Death can ruin a good sleepless day (5.00 / 1) (#8)
by SEWilco on Tue Nov 11, 2003 at 06:29:55 PM PST
The explanation for sleep which makes the most sense to me was pointed out just a few years ago: The bloodstream simply can't deliver as much energy as a brain needs.

All animals sleep, despite the huge evolutionary advantage if one did not have to sleep.  This suggests something ancient in the biology of the brain requires sleep.  Even fruit flies need sleep.

The researcher who pointed this out thinks it's simply the basic chemicals needed by neurons which cause the problem.  The bloodstream can't deliver enough glucose and nutrients to meet the demands of an operational brain.  Apparently it can to other neurons, but not to a brain.

So sleep is simply a time when the brain is slowed down and operation altered so neurons and glial cells can be recharged.

This explains a lot about sleep deprivation.  Visual hallucinations, starting with the "bug flickers" in peripheral vision as the motion-sensing systems malfunction.  Altered thinking and states of consciousness.  And death if the autonomic systems malfunction.

In humans, 48 hours can often be achieved by prepared individuals.  So I'm not surprised at easy enhancement of the quality of 40 hours in young military men in good condition.

Although it is interesting that Japan's oldest woman recently died, and she was known for her habit of staying awake for 2 days and then sleeping for 2 days.



The 50 Best Guy Movies Of All Time (5.00 / 1) (#11)
by Anonymous on Thu Nov 13, 2003 at 06:24:22 AM PST
It looks like they listed all 50 movies, there is a set of links at the bottom of the first page to get to the rest it looks like: Best Guy Movies: 1-10 | 11-20 | 21-30 | 31-40 | 41-50



more trigger-happy soldiers? (4.00 / 1) (#1)
by m1fcj on Tue Nov 11, 2003 at 08:26:19 AM PST
Is this really a good thing? I'm not convinced of having "apparently no side-effects".

I know the existing drugs make soldiers/pilots more jumpy, resulting in a lot of friendly-fire incidents. I just can't believe such a thing would have no side effects.



"Terminator" as a "Guy Movie"? (4.00 / 1) (#3)
by Sweetwind on Tue Nov 11, 2003 at 09:19:50 AM PST
"Men's Journal" rates "The Terminator" as a "Guy Movie"?! I hate to break it to those guys, but I see it as a Chick Flick that just happens to have explosions in it. After all, the heroine finds her One True Love, a Love that is her Destiny! A Love that Transcends Time!

They cite "Violence trumps sex" as one of their criteria, but the fact is, I remember the love scene pretty clearly (ooh la la!), and I have no memory whatsoever of the dance club massacre. "A movie only a guy can love. ... your wife or girlfriend should run screaming from the room" - no, no, no. We'll be sitting right there with you for this one (fantasizing about being on the run with Michael Biehn).



Wish we had this when I was in university... (3.00 / 1) (#2)
by Drog on Tue Nov 11, 2003 at 08:52:26 AM PST
When we had to stay awake studying, we used the "snowy-buds-o-coffee" trick. That's where you take the inside of an oreo cookie and roll it in coffee grinds. Mmmmmm.

Looking for political forums? Check out "The World Forum".


Article Links (none / 0) (#12)
by jcunnin on Tue Dec 02, 2003 at 01:23:53 PM PST
Here is the article referenced and some others:
Men's Journal Article
Wired Article
LA Time's Article




Provigil (none / 0) (#13)
by Anonymous on Fri May 13, 2005 at 02:59:54 PM PST
Just a quick comment. My husband has bipolar disorder and was prescribed Provigil to counteract the drwsy effects of the lithium. After two months on Provigil, I had an al out junkie for the stuff and for the first time in 20 years got to witness a full blown episode of mania. It was terrifying. May I add that after his Provigil was taken away...and no he was not taking it other than as prescribed, he screamed, yelled and fought to get it back. He didn't but now we have a major stimulant problem as he has replaced it with caffeine, sugar and ephidrine. He's put on 30 pounds in two months and is on the brink of rapid cycling EVERDAY! AWESOME product... at times he didn't sleep for days. THIS PRODUCT HAS ADDICTIVE PROPERTIES AND SHOULD BE MORE CAREFULLY CONSIDERED BEFORE PRESCRIBING IT TO SOMEONE WITH BIPOLAR DISORDER!



Sleep Is Now An Option | 13 comments (13 topical, 0 hidden)

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Related Science Links
· Provigil
· Men's Journal
· 50 Best Guy Movies of All Time
· Provigil [2]
· a letter of approval from the FDA
· swing-shif t syndrome
· caffeine in No-Doze
· For soldiers, the answer is yes
· want some
· erase your fears and phobias
· More on Cognitive Science
· Also by rickyjames

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