By rickyjames, Section News Posted on Tue Nov 11, 2003 at 12:59:20 AM PST
I read a very interesting article on Provigil in the December 2003 issue of Men's Journal. It's not online, so pick a copy up at the newsstand and check it out - it's the one with Kid Rock on the cover. It's worth buying just for the other article about the 50 Best Guy Movies of All Time - which they do list online to tease you into, you got it, picking a copy up on the newsstand.
Now where was I? Oh, yes, Provigil. It was a drug originally developed to treat narcolepsy, the inability to stay awake. Now Cephalon, the maker of Provigil, has received a letter of approval from the FDA extending the approved uses of the drug to treatment of jet-lag and swing-shift syndrome. In reality the the drug is set to replace the caffeine in No-Doze as the all-nighter anti-sleep aid of choice. In fact, it's much better than No-Doze - with Provigil, you can literally stay awake for days, alert and with a remarkable lack of side effects. For example, a 1995 Canadian study showed that subjects taking the drug were able to perform well on cognitive tests while remaining awake and in good spirits for two and a half days. "This drug is going to bring up some very interesting ethical dilemmas," says Dr. Mark Mahowald, director of the Minnesota Regional Sleep Disorders Center in Minneapolis and an expert on the causes of daytime sleepiness. "Do you prescribe a stimulant medication for someone who is intentionally sleep deprived?"
For soldiers, the answer is yes. In another study, published in 2000, U.S. Army helicopter pilots stayed awake for 40 hours while being called upon periodically to perform maneuvers on a flight simulator. Unmedicated, the aviators became sloppy and made errors in the early morning hours. But while taking Provigil during a second 40-hour marathon, their skills and focus never wavered. Army psychologist John Caldwell, who conducted the latter study, says more research is needed to determine whether dosing soldiers with Provigil is a safe and effective way to promote alertness. However, he says, it's possible that one day the drug could be used "as an emergency measure to briefly overcome fatigue in 'must-do' missions where total sleep deprivation is unavoidable."